Anesthesiologist Assistant is The Premier Employment-Solutions website for Anesthesia Professionals and Hiring Companies !

HomeMy ProfileSearch JobsPost Profile/CVPost JobsResources
  FAQ FAQ  Forum Search   Calendar   Register Register  Login Login

AA's Thoughts On Malignant Hyperthermia

 Post Reply Post Reply
  Topic Search Topic Search  Topic Options Topic Options
JCole View Drop Down
Senior Member
Senior Member

Joined: 03 Oct 2007
Location: United States
Online Status: Offline
Posts: 128
  Quote JCole Quote  Post ReplyReply Direct Link To This Post Topic: AA's Thoughts On Malignant Hyperthermia
    Posted: 17 Sep 2009 at 9:50pm
Malignant Hyperthermia


Malignant hyperpyrexia is life-threatening genetic sensitivity to volatile anesthetic agents and depolarising skeletal muscle relaxants



    * Tachycardia, supraventricular and ventricular arrhythmias
    * Cardiac arrest
    * Increase in ETCO2 or hyperventilation
    * Masseter spasm and generalised rigidity
    * Skin discolouration, sweating, cyanosis



Dantrolene is the only clinically available drug for specific treatment of malignant hyperthermia.

    * Suspicion of malignant hyperpyrexia
    * Immediate withdrawal of all precipitating agents (Inhalational anesthetics, Depolarising muscle relaxants)
    * 100% Oxygen and hyperventilation
    * maintain anesthesia with Opioids, Intravenous anaesthetics and nondepolarising muscle relaxants
    * Terminate surgery as soon as possible
    * Prepare and administer dantrolene
    * Dantrolene bolus 2.5mg/kg IV
    * repeat dantrolene bolus at 5 minute intervals
    * Continue with IV infusion of dantrolene at rate of 10mg/kg/day for at least 24 hours
    * Concurrently provide supportive care
          o Body cooling
          o Correct acidosis with sodium bicarbonate
          o Beta-blockers
          o Treat hyperkalaemia, hypercalcaemia, myoglobinuria


Krause T, Gerbershagen et al: Dantolene- A review of its pharmacology, therapeutic use and new developements. Anesthesia 2004; 59:364-373

------------------------------------------------------------------------------------------------------------------- = Doctorate Of Nurse Anesthesia Practice


Anesthesiologist Assistant Resource Websites:

Edited by JCole - 17 Sep 2009 at 9:54pm
Back to Top
 Post Reply Post Reply

Forum Jump Forum Permissions View Drop Down

Bulletin Board Software by Web Wiz Forums® version 9.05
Copyright ©2001-2007 Web Wiz

This page was generated in 0.047 seconds.


Contact Us - Privacy Policy - Terms of Use - Advertising


AnestaWeb, Inc - All Rights Reserved

SSL Certificate Authority